Underrepresentation of women in clinical trials and lack of sex-specific reporting

It has been 20 years since the first requirements to include women as well as men in clinical trials and analyze results by sex were mandated by a U.S. federal law, yet not nearly enough progress has been made. Recent signs of potential change in both policy and practice of scientific inquiry suggest much more progress may be within reach. Specific instrumental recommendations are offered for how to include the study of sex and gender in research so as to increase our understanding and promotion of health for the benefit of all.

Only a few cardiovascular trials provide sex-specific data. Sex differences remain poorly understood, and this deficiency limits our ability to optimize medical care for both sexes.